Brand: EXIT EXTREME

Company: MERIAL


FORMULATION: «pour-on» for topical administration.

ACTIVE INGREDIENT(S)

CHEMICAL CLASS of the active ingredient(s):


INDICATIONS: SHEEP

PARASITES CONTROLLED (spectrum of activity)

  • Body lice (Bovicola ovis = Damalinia ovis) in on all breeds of sheep.
  • Blowfly strike (incl. Lucilia cuprina) in coarse wool sheep.

RECOMMENDED DOSE*

* Read the product label for further details on dosing and administration.

Lice control
Dose Volume mL (1) Dose Volume mL (2) Bodyweight Number of bands
For the prevention of body strike
7 10 ≤10kg 2
8.5 12 10.1-30 kg 2
10.5 15 20.1-30 kg 2
13.5 20 30.1-55 kg 2
17 25 55.1-75 kg 2
3 mL/10kg 17 > 75 kg 1
Apply in a single strip down the middle of the back between the poll and the tail base using the special applicator gun & noozle.
Blowfly Control
Dose Volume mL Bodyweight
2 x 5 mL ≤10kg
2 x 6 mL 10.1-30 kg
2 x 7.5 mL 20.1-30 kg
2 x 10 mL 30.1-55 kg
2 x 12.5 mL 55.1-75 kg
2 x 2.5 ml/10 kg > 75 kg
Apply half the dose in a single strip from the poll to the tail base and half the dose in a second stroke around the crutch using the special applicator gun & noozle.

SAFETY

  • LD50 (acute oral) in rats:
    • Cypermethrin a.i. 250 mg/kg (in corn oil) to 5150 mg/kg (in water)
    • Trifumuron a.i. > 5000 mg/kg
  • Estimated hazard class of the a.i. according to the WHO classification of pesticides: U, unlikely to present acute hazard in normal use.

Suspected poisoning? Read the article on cypermethrin safety in this site. Triflumuron is an IGR with rather low toxicity for mammals.

Withholding periods (=withdrawal times) for meat, milk (country-specific differences may apply: read the product label)

  • Meat: New Zealand: 49 days
  • Milk for human consumption: New Zealand: Milk intended for sale for human consumption must be discarded during treatment and for not less than 35 days following the last treatment.

You may be interested in the following articles in this site dealing with the general safety of veterinary products:


RESISTANCE PREVENTION

Risk of resistance? YES

Resistance of body lice (Bovicola = Damalinia ovis) to synthetic pyrethroids is widespread in Australia and has been reported in New Zealand too. Resistance of blowfly strike to triflumuron and other benzoylureas is widespread in both countries as well.  

This means that if this product does not achieve the expected efficacy against the mentioned parasites, it can be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.

It is generally accepted that the use of mixtures of active ingredients with different modes of action against a given parasite can delay the appearance of resistance. But only if the concerned parasites are susceptible to all the actives in the mixture. If not, the mixture is likely to promote multi-resistant parasites, because the selection pressure against all actives remains in place. Mixtures such as this one may provide peace-of mind to those users that do not know the resistance status of parasites in their property: at least one of the actives will work... This may be the case for a while. But the risk that some parasites become resistant to all components after a few years using the same or comparable mixtures is considerable. If it is not too late, a better alternative is to determine the resistance status in the property and to rotate among products (not mixtures) against which the parasites have not yet developed resistance, stopping the use of those chemical classes that have already shown resistance problems.

Alternative chemical classes/active ingredients for product rotation to prevent resistance development:

These alternative products may not be available in all countries, or may not be available as pour-ons.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • GENERICS

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: New Zealand
GENERIC BRANDS available? YES, but rather few, if at all with this particular composition.

Click here to learn more about GENERIC vs. ORIGINAL drugs.

For an overview on the most used antiparasitic pour-on brands click here.


COMMENTS

EXIT EXTREME is a pour-on for sheep from MERIAL combining 2 active ingredients with different modes of action against both body lice and blowfly strike, cypermethrin and triflumuron.

Cypermethrin is one of several Type-II synthetic pyrethroids, introduced by ICI & SHELL in the 1970s. It is a broad-spectrum insecticide and acaricide, not particularly effective against blowfly strike. Worldwide it is massively used in veterinary products as well as in agricultural and hygiene pesticides. All synthetic pyrethroids are veteran pesticides developed in the 1970s-1980s and are basically contact insecticides. This means that when the parasite comes in contact with it (e.g., during the blood meal, after landing on a treated host, etc), the active ingredient that impregnates the host's hair coat penetrates through the cuticle of the parasite (the "skin" of insects and other arthropods) into its organism and disturbs essential biological processes in the parasite's body, in this case its nervous system.

Triflumuron is a broad-spectrum insect growth regulator (IGR) belonging to the benzoylphenyl-ureas introduced in the 1980s (by BAYER). It is effective against immature stages (larvae, nymphs, etc.) of numerous insects but not against adult stages. It is used in sheep and horses but only in Australia and New Zealand, not in Europe or the US. It is not used so far in other livestock or in pets. It is also used moderately against agricultural and household pests.

It is important to understand that insect growth regulators do not kill adult lice that may infect animals at the moment of treatment, i.e. they don't have a knock-down effect. What they do is to prevent further development of immature stages. Larvae and/or nymphs fail to molt to the next stage and die. Thus infected animals treated may need a few weeks to become free of lice. Cypermethrin may kill adult lice if the have not developed resistance.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

Other interesting articles