Brand: ZEROMEC ® PREMIX
Company: ABBEY LABORATORIES
FORMULATION: «feed additives and medicated feeds» for oral administration.
ACTIVE INGREDIENT(S): ivermectin: 6 mg/g (=0.6%)
CHEMICAL CLASS of the active ingredient(s): macrocyclic lactone
PARASITES CONTROLLED* (spectrum of activity)
* Country-specific differences may apply: read the product label
- Gastrointestinal roundworms: Ascaris suum (adults and L4 larvae), small stomach worm Hyostrongylus rubidus (adults and L4 larvae), nodule worm Oesophagostomum spp (adults and L4 larvae), threadworm Strongyloides ransomi (adults and somatic larvae, stomach worm Ascarops strongylina (adults)
- Kidney worms: Stephanurus dentatus (adults and L4 larvae),
- Lungworms: Metastrongylus spp (adults).
- Lice: Haematopinus suis.
- Mange mites: Sarcoptes scabiei var. suis.
- Given to pregnant sows for 7 consecutive days starting 2-3 weeks before farrowing effectively controls transmission via the milk of Strongyloides ransomi to piglets.
*Can be slightly different in some countries: read the product label!
- In-feed use. For the production of medicated feedingstuff.
- The recommended dose level is 100 mcg ivermectin/kg liveweight daily for 7 days.
- Read the product label for specific directions for use.
- LD50 (acute oral) in rats: ~4167 mg/kg (estimate according to WHO 2009 recommendation)
- Estimated hazard class according to the WHO: not applicable for veterinary medicines
Suspected poisoning? Read the article on ivermectin safety in this site.
Withholding period for meat (country-specific differences may apply: read the product label)
- Swine: AUS 7 days
WARNING !!!: Never use on humans, dogs and cats
Risk of resistance? NO
Resistance of gastrointestinal roundworms to ivermectin has not been reported yet in swine, in contrast with sheep, goats, cattle and horses, where it is very frequent worldwide.
This means that if this product does not achieve the expected efficacy against the mentioned parasites, it is likely to be due to incorrect use not to resistance
Alternative chemical classes/active ingredients to prevent resistance of gastroinitestinal roundworms through product rotation:
- Benzimidazoles, e.g. albendazole, febantel, fenbendazole, oxfendazole, etc. Similar or even worse resistance problems than macrocyclic lactones
- Imidazothiazoles, mainly levamisole. etc. Similar or even worse resistance problems than macrocyclic lactones
- Tetrahydropyrimidines, e.g. morantel, pyrantel (limited spectrum of activity)
These alternative products may not be available in all countries, or may not be available as injectables.
Although strictly speaking it is not yet needed, it may be advisable to rotate occasionally.
Learn more about resistance and how it develops.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this product is marketed: Australia
GENERIC BRANDS available? YES, numerous.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
Click here for an overview on the most used antiparasitic feed additives and medicated feeds for livestock and horses.
This product from ABBEY LABORATORIES is a generic brand for swine with ivermectin.
The original brand, IVOMEC PREMIX, was introduced in the 1980s as a specific oral formulation of ivermectin for swine.
Ivermectin was the first macrocyclic lactone discovered and introduced in the 1980s by MS&D AgVet (later MERIAL). It is the parasiticide for livestock and pets most widely used worldwide, with probably thousands of generic brands. Ivermectin is probably the best veterinary parasiticide ever developed, highly effective against roundworms as well as against numerous external parasites (ticks, flies, lice, mites, etc.). As all macrocyclic lactones, ivermectin used alone is ineffective against tapeworms and flukes, regardless of the delivery form.
There are also numerous mixtures of ivermectin with other active ingredients (not as premix for swine) as well as other formulations (injectables, pour-ons, drenches).
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional