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Cypermethrin is a synthetic pyrethroid highly effective against many external livestock and pet parasites (flies, ticks, mites, lice, fleas, mosquitoes, etc.). It is completely ineffective against internal parasites.

As all synthetic pyrethroids, cypermethrin products are always used for topical administration, either as concentrates for dipping or spraying, or in ready-to-use products such as pour-ons, dressingsear-tags for cattle, sheep, pigs and horses, and spot-ons or low-cost topicals for dogs such as shampoos, soaps, sprays, etc. Cypermethrin is used massively in livestock worldwide, with hundreds of different brands. Use in pets is quite modest because permethrin is often preferred. It is also used massively in crop protection and household pesticides.

Dosing and efficacy of cypermethrin products depends a lot on its cis:trans isomeric composition (e.g. 40:60, for most products; 80:20 =cypermethrin high-cis; 100% = alphacypermethrin, or alphamethrin). The higher the cis-isomer content, the higher the efficacy at the same dose, or the lower the dose required to achieve the same control than with the low-cis product. Unfortunately many manufacturers do not indicate the cis:trans composition in the product labels, which may create confusion.

However, resistance to all synthetic pyrethroids is already very frequent worldwide and can be extremely high, particularly in cattle ticks, horn & buffalo flies, houseflies, red fowl mites, mosquitoes, sheep lice, etc.

The table below indicates some usual dosing recommendations for cypermethrin issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.

Dosing recommendations for CYPERMETHRIN
DOGS
Delivery Parasites Dose (against cypermethrin-susceptible parasites)
Bath Fleas, ticks, lice, mites, etc. 100-200 ppm (=mg/L) in the wash, dep. on isomers & indications
Spot-on Fleas, ticks, lice, mites, etc. 5-12 mg/kg
CATS. Pyrethroids are mostly toxic to cats!
CATTLE
Delivery Parasites Dose (against cypermethrin-susceptible parasites)
Dip, spray Ticksflies, mites, lice, etc. 50-400 ppm (=mg/L) in the wash dep. on isomers & indications
Pour-on Ticksflies, mites, lice, etc. 1-20 mg/kg, dep. on isomers & indications
SHEEP & GOATS
Delivery Parasites  Dose (against cypermethrin-susceptible parasites)
Dip, spray Ticksflies, lice, mites, etc. 50-400 ppm (=mg/L) in the wash dep. on isomers & indications
Pour-on Ticksflies, lice, mites, etc. 1-15 mg/kg, dep. on isomers & indications
SWINE 
Delivery Parasites  Dose (against cypermethrin-susceptible parasites)
Spray Lice, mites 50-400 ppm (=mg/L) in the wash dep. on isomers & indications
Pour-on Lice, mites 2-10 mg/kg, dep. on isomers & indications
HORSES
Delivery Parasites  Dose (against cypermethrin-susceptible parasites)
Spray Ticks, flies, lice, mites, etc. 50-400 ppm (=mg/L) in the wash dep. on isomers & indications
Pour-on Ticks, flies, lice, mites, etc. 1-20 mg/kg, dep. on isomers & indications
POULTRY
Delivery Parasites  Dose (against cypermethrin-susceptible parasites)
Spray Ticksflies, mites, lice, etc. 50-400 ppm (=mg/L) in the wash dep. on isomers & indications

DISCLAIMER: Liability is denied for any possible damage or harm to persons, animals or any other goods that could follow the transmission or use of the information, data or recommendations in this site by any site visitor or third parties.

In most finished products, efficacy and safety depend not only on the amount of active ingredient(s) but also on their formulations (i.e. the type and amount of so-called inert ingredients), particularly in injectables and in topical pour-ons and spot-ons. These inert ingredients can significantly affect the pharmacokinetic behavior (e.g. absorption through the skin or from the injection site, distribution within the body, spreading throughout the body surface, etc). Generic products usually contain the same amount of active ingredient(s) as the original product, but often in quite different formulations. In many cases, the curative (therapeutic) efficacy of the different formulations is quite comparable, but the protective (prophylactic) efficacy that determines the length of protection against re-infestations may be rather different.

Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.


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