Company: HORIZON AGRESOURCES
FORMULATION: «injectable» to be administered subcutaneously.
ACTIVE INGREDIENT(S): doramectin: 10 mg/mL =1%
CHEMICAL CLASS of the active ingredient(s): macrocyclic lactone
PARASITES CONTROLLED* (spectrum of activity)
* Country differences may apply: read the product label!
- Gastrointestinal roundworms: Adult worms and immature stages of Ostertagia ostertagi (incl. inhibited larvae), Ostertagia lyrata, Trichostrongylus spp (Stomach hair worm), Trichostrongylus colubriformis (Black scour worm), Trichostrongylus longispicularis (adults sonly), Cooperia oncophora (Small intestinal worm), Cooperia punctata, Cooperia surnabada (mcmasteri), Oesophagostomum radiatum (Nodule worm), Bunostomum phlebotomum (Hookworm, adults only), Nematodirus spathiger (adults only), Strongyloides papillosus (adults only), Trichuris spp (adults only).
- Lungworms adult & immature: Dictyocaulus viviparus.
RECOMMENDED DOSE *
- 1 ml product/50 kg, equivalent to: doramectin 200 mcg/kg bw.
Read the product label for further details on dosing.
- LD50 (acute oral) in rats: a.i. 50 mg/kg
- Estimated hazard class according to the WHO: not applicable for veterinary medicines
Suspected poisoning? Read the article on on doramectin safety in this site.
Withholding periods (=withdrawal times) in days for meat & milk (country-specific differences may apply: read the product label)
- Meat: New Zealand 42 days.
- Milk for human consumption: New Zealand: Milk intended for sale for human consumption must be discarded during treatment and for not less than 42 days following the last treatment.
WARNING !!!: Never use on humans, dogs or cats
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance of gastrointestinal roundworms to macrocyclic lactones (incl. doramectin): YES, reported in cattle in numerous countries particularly in the following worm species: Cooperia spp, Ostertagia spp, Haemonchus spp, Trichostrongylus spp, Oesophagostomum spp.
Resistance of gastrointestinal roundworms to macrocyclic lactones (incl. abamectin) in sheep, goats and cattle has been reported almost worldwide, including the USA, UK, Australia and New Zealand. Based on the very abundant and frequent use of ivermectin and other macrocyclic lactones (with cross-resistance to ivermectin) in livestock it must be assumed that resistance of these roundworms to this chemical class will continue spreading and strengthening in the future.
Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation:
- Benzimidazoles, e.g. albendazole, febantel, fenbendazole, oxfendazole, etc. Similar or even worse resistance problems than ivermectin
- Imidazothiazoles, mainly levamisole. etc. Similar or even worse resistance problems than ivermectin
- Nitroxinil (limited spectrum of activity)
- Tetrahydropyrimidines, e.g. morantel, pyrantel (limited spectrum of activity)
- Salicylanilides, e.g. closantel (limited spectrum of activity)
These alternative products may not be available in all countries, or may not be available as injectables.
This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.
Learn more about resistance and how it develops.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed: New Zealand
GENERIC BRANDS available? Yes a few ones. This product contains itself generic doramectin.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
For an overview on the most used antiparasitic injectable brands for livestock click here.
DORAJECT Injectable Solution for CATTLE from HORIZON AGRESOURCES with generic doramectin is one of the numerous injectables with macrocyclic lactones for cattle. It is a generic version of DECTOMAX from ZOETIS.
Doramectin is a broad spectrum macrocyclic lactone introduced in the 1990s (by PFIZER, now ZOETIS) for use in livestock. It's spectrum of activity is similar to that of ivermectin. It is generally considered as more potent than ivermectin against gastrointestinal nematodes of livestock, particularly in sheep and goats, and against a few other livestock pests (e.g. sheep scab, cattle ticks, etc.). It is also less toxic than ivermectin, which allows higher safety margins. It is not used in poultry, only marginally in horses, and not at all in pets. It is not used in agriculture.
Being an excellent antiparasitic, doramectin does not control all parasites of livestock. Unfortunately advertising and even the label of some generic formulations in less developed countries often include unsubstantiated claims. To help preventing confusion and misuse it is useful to know that whatever doramectin 1% injectable used at the recommended dose, it DOES NOT CONTROL:
- Ticks (e.g. Amblyomma spp, Rhipicephalus spp, Dermacentor spp, Haemaphysalis spp, Hyalomma spp, Ixodes spp, etc.)
- Flies (e.g. horn flies, houseflies, stable flies, black flies, horse flies, etc.)
- Fleas (e.g. Ctenocephalides spp)
- Blowfly strike of sheep
- Tapeworms (e.g. Moniezia spp spp)
- Flukes (e.g. liver fluke Fasciola hepatica)
Click here for general information on good practices for the prevention and control of gastrointestinal worms in livestock.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.