Brand: GENESIS TAPE Hi Mineral Oral Drench
Company: BOEHRINGER INGELHEIM (MERIAL)
DELIVERY FORM: «drench» for oral administration.
- Abamectin: 1.0 mg/mL (equivalent to 0.1%)
- Praziquantel: 18.8 mg/mL (equivalent to 1.88%)
- Iodine 1.0 mg/mL, Cobalt 0.2 mg/mL, Copper 2.1 mg/mL, Zinc 0.6 mg/mL, and Selenium 0.5 g/L: without anthelmintic efficacy.
CHEMICAL CLASS of the active ingredient(s):
- Abamectin: macrocyclic lactone
- Praziquantel: isoquinoline
INDICATIONS: SHEEP (LAMBS)
PARASITES CONTROLLED* (spectrum of activity)
* Country differences may apply: read the product label!
- Adult and immature gastrointestinal roundworms:Haemonchus spp (incl. L4 inhibited larvae), Teladorsagia (Ostertagia) spp (incl. L4 inhibited larvae), Trichostrongylus spp, Cooperia spp (incl. L4 inhibited larvae), Nematodirus spp (adults only), Oesophagostomum spp (adults only), Dictyocaulus spp
- Tapeworms: Moniezia expansa
1 ml product per 5 kg bodyweight, equivalent to:
- 0.2 mg/kg abamectin
- 3.75 mg/kg praziquantel
Read the product label for further details on dosing
- LD50 (acute oral) in rats:
- Abamectin: 10 mg/kg (for the a.i.)
- Praziquantel: >2840 mg/kg (for the a.i.)
Suspected poisoning? Read the articles on abamectin safety and praziquantel safety in this site.
Withholding periods (=withdrawal times) for meat & milk (country-specific differences may apply: read the product label)
- Meat: New Zealand: 14 days
- Milk for human consumption: New Zealand: Milk intended for sale for human consumption must be discarded during treatment and for not less than 35 days following the last treatment.
WARNING !!!: Never use on humans, dogs or cats
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance? YES
Unfortunately, resistance of several gastrointestinal roundworms to abamectin (and other macrocyclic lactones) is already very high and very frequent worldwide in sheep and goats. Cases of multiple resistance (i.e. simultaneous) to more than one chemical class have also been reported. Most affected worm species are: Haemonchus spp, Ostertagia spp /Teladorsagia spp, Trichostrongylus spp, Nematodirus spp, Chabertia ovina.
This means that if this product does not achieve the expected efficacy against the mentioned parasites, it can be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.
Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation:
- Benzimidazoles, e.g. albendazole, febantel, fenbendazole, oxfendazole, etc. Similar or even worse resistance problems than macrocyclic lactones
- Imidazothiazoles, mainly levamisole. etc. Similar or even worse resistance problems than macrocyclic lactones
- Derquantel: available so far only for sheep in combination with abamectin.
- Monepantel: available only for sheep & goats in some countries (e.g. Australia, UK & EU, New Zealand). First cases of resistance reported in New Zealand in 2013.
- Salicylanilides (e.g. closantel): effective only against certain gastrointestinal roundworms. Not available in some countries. Resistance to closantel has been reported in some countries.
- Tetrahydropyrimidines (e.g. morantel, pyrantel): effective only against certain gastrointestinal roundworms. Not available in some countries. Resistance to morantel has been reported in some countries.
- Nitroxinil: effective only against certain gastrointestinal roundworms (e.g. Bunostomum spp, Haemonchus spp, Oesophagostomum spp). Not available in some countries.
These alternative products may not be available in all countries, or may not be available as drenches, or may not be effective against all the concerned parasites.
It is highly recommended to periodically check the resistance status of each property performing appropriate tests (e.g. fecal egg counts) under supervision of a veterinary doctor. Such tests are now routinely available for most producers in developed countries.
Learn more about resistance and how it develops.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
- Abamectin: GENERIC (introduced in the 1980s)
- Praziquantel: GENERIC (introduced in the 1970s)
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed: New Zealand
GENERIC BRANDS available? Yes, in Australia and/or New Zealand, not elsewhere. This product itself contains generic active ingredients.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
For an overview on the most used drench brands for livestock click here.
GENESIS TAPE Hi Mineral Oral Drench is a brand combining 2 active ingredients. Abamectin is effective against gastrointestinal roundworms and praziquantel is effective exclusively against tapeworms.
Abamectin, one of the first macrocyclic lactones developed, was introduced already in the 1980s (by MSD AGVET). As all macrocyclic lactones, abamectin is an endectocide, i.e. it is simultaneously effective against some external parasites and against internal parasites (mainly roundworms). As for other macrocyclic lactones, abamectin has no efficacy whatsoever against tapeworms and flukes. Abamectin is considered as the "cheap" ivermectin, with a similar spectrum of efficacy but less potent and slightly more toxic. It is abundantly used in ruminants, much less in pig, poultry and pets. Abamectin is also used in agricultural and hygiene pesticides worldwide. Interestingly abamectin is widely used on livestock in Australia and New Zealand but insignificantly in the EU, the USA and Canada, if at all.
Praziquantel is a veteran narrow-spectrum anthelmintic introduced in the 1970s (by BAYER). It is highly effective against tapeworms but has no efficacy whatsoever against roundworms. It is the anthelmintic most vastly used against tapeworms in horses and pets, with hundreds of brands, usually in combination with a nematicide against roundworms. It is hardly used in livestock. It is not used in agriculture.
Praziquantel administered as a drench has no residual effect, i.e. it kills the parasites shortly after administration, but does not significantly protect the animals against re-infestation by infective stages in their environment.
In ruminants, reducing the amount of feed slows down the exit flow of the rumen and prolongs the time during which the active ingredient remains there and is absorbed. Consequently it is advisable to reduce the access of animals to feed (especially to fresh pasture, not to water) 24 hours before administration. For the same reason, it is better to keep the animals away from food for about 6 hours after drenching. However sick or weak animals should not be kept away from food and fasting animals should have access to water.
Thoroughly shaking suspensions before use is crucial for efficacy. If the active ingredient remains in the sediment, a few animals may get most of the active ingredient and will be overdosed, and the large majority will get almost only solvents and will be underdosed.
Click here for general information on good practices for the prevention and control of gastrointestinal worms in livestock.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.