Brand: IVOMEC ® MAXIMIZER
Company: BOEHRINGER INGELHEIM (MERIAL)
DELIVERY FORM: controlled release capsule for oral administration.
ACTIVE INGREDIENT(S): ivermectin
- for adult sheep: 160 mg/capsule
- for weaner sheep: 80 mg/capsule
CHEMICAL CLASS of the active ingredient(s): macrocyclic lactone
INDICATIONS: SHEEP
PARASITES CONTROLLED (spectrum of activity)
Sheep
For the treatment and 100 day control of sensitive strains of gastrointestinal roundworms and lungworms in sheep.
- Barber’s Pole Worm: Haemonchus contortus
- Small Brown Stomach Worm: Teladorsagia (Ostertagia) circumcincta, O. trifurcata, including inhibited L4
- Stomach Hair Worm: Trichostrongylus axei - including inhibited L4
- Black Scour Worm: Trichostrongylus colubriformis, Trichostrongylus vitrinus
- Small Intestinal Worm: Cooperia curticei, Cooperia oncophora
- Thin-Necked Intestinal Worm: Nematodirus spathiger, Nematodirus filicollis
- Large Mouthed Bowel Worm: Chabertia ovina
- Nodule Worm: Oesophagostomum columbianum
- Large Bowel Worm: Oesophagostomum venulosum
- Whip worm: Trichuris ovis
- Intestinal threadworm: Strongyloides papillosus
- Lungworms: Dictyocaulus viviparus, Protostrongylus rufescens
- Nasal Bot: Oestrus ovis
- Itch mites: Psorergates ovis.
- Keds: Melophagus ovinus
RECOMMENDED DOSE*
* Country-specific differences may apply: read the product label.
- One 160 mg capsule per animal weighing 40 to 80 kg. 2 capsules for animals over 80 kg.
- One 80 mg capsule per animal weighing 20 to 40 kg.
SAFETY
- LD50 (acute oral) in rats: for the a.i. 50 mg/kg (source: MSDS)
- LD50 (acute dermal) in rats: for the a.i. >660 mg/kg (source: MSDS)
Suspected poisoning? Read the articles on ivermectin safety in this site.
Withholding periods (=withdrawal times) for meat & milk (country-specific differences may apply: read the product label)
- Meat: 126 days (ESI 126 days)
- Milk for human consumption: Do not use in female sheep which are producing, or may in the future produce, milk or milk products for human consumption.
WARNING !!!: Never use on humans, dogs or cats
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
RESISTANCE PREVENTION
Risk of resistance? YES
Unfortunately, resistance of several gastrointestinal roundworms to ivermectin (and other macrocyclic lactones) is already very high and very frequent worldwide in sheep and goats.
This means that if this product does not achieve the expected efficacy against the mentioned parasites, it can be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.
Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation:
- Benzimidazoles, e.g. albendazole, febantel, fenbendazole, oxfendazole, etc. Similar or even worse resistance problems than ivermectin.
- Derquantel: available so far only in combination with abamectin.
- Imidazothiazoles, mainly levamisole. etc. Frequent resistance problems as well.
- Monepantel: available only for sheep & goats in some countries (e.g. Australia, UK & EU, New Zealand). First cases of resistance reported in New Zealand in 2013.
- Salicylanilides, e.g. closantel (limited spectrum of activity).
- Tetrahydropyrimidines (e.g. morantel, pyrantel): effective only against certain gastrointestinal roundworms. Not available in some countries. Resistance to morantel has been reported in some countries.
- Nitroxinil: effective only against certain gastrointestinal roundworms (e.g. Bunostomum spp, Haemonchus spp, Oesophagostomum spp). Not available in some countries.
These alternative products may not be available in all countries or may not be effective against all the concerned parasites.
It is highly recommended to periodically check the resistance status of each property performing appropriate tests (e.g. fecal egg counts) under supervision of a veterinary doctor. Such tests are now routinely available for most producers in developed countries.
Learn more about resistance and how it develops.
MARKETING
Are the active ingredients of this product ORIGINAL* or GENERICS**?
- Ivermectin: GENERIC (introduced in the 1980s)
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed: Australia, New Zealand
GENERIC BRANDS available? NOT in the form of capsules so far; dozens in the form of injectables or drenches.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
For an overview on the most used drench or capsule brands for livestock click here.
COMMENTS
IVOMEC MAXIMIZER is a slow-release capsule brand with original ivermectin. Ensures 100 day control of ivermectin-sensitive strains of internal and external parasites.
Ivermectin was the first macrocyclic lactone introduced in the market in the early 1980s (by MSD AGVET, later MERIAL). It was a milestone and a tremendous progress that revolutionized the control of veterinary parasites. Depending on the delivery form and the dose it is effective against most species of roundworms that affect ruminants and against many external parasites (mainly lice, mites, etc), but not against tapeworms or flukes. Nowadays and worldwide there are hundreds if not thousands of veterinary antiparasitics for livestock, horses or pets containing ivermectin alone or in combination with other active ingredients. Ivermectin is also used in agricultural pesticides.
Click here for general information on good practices for the prevention and control of gastrointestinal worms in livestock.
DISCLAIMER
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.